Cytogenetics

The 1024 x 1024 frame transfer format offers unequalled thermoelectric cooling down to -95°C and industry-lowest clock induced charge noise. EMCCD and conventional CCD readout modes provide heightened application flexibility. The iXon3 888 high sensitivity EMCCD camera benefits from an advanced set of user–requested features, including OptAcquire, Count Convert, Spurious Noise Filters, Cropped Sensor Mode, Signal Averaging and enhanced Photon Counting capability. Patented EMCAL™ and RealGain™ provide sustained quantitative EM gain calibration.

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Andor iXon3
iXon 888

Nikon’s A1R MP multiphoton confocal microscope is a unique multiphoton imaging system featuring a fast, high resolution galvanometer scanner and an ultra-high speed resonant scanner that is capable of frame rates from 30 fps at 512 x 512 pixels to as fast as 420 fps in band scan mode. New 4 channel non-descanned detectors with higher sensitivity, reduced dark current and broad spectral range allow for real time unmixing of closely spaced probes for accurate and high-contrast spectral imaging. This is especially important in multiphoton microscopy because of the overlap of emission spectra of probes and autofluorescence, which is often unavoidable when using a single laser line.

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A1R-MP+

autoFIND F coupled to microFIND^®, the innovative device developed by Tethis, is an automated slide staining system for the processing of the majority of the steps of the FISH (Fluorescent In Situ Hybridization) assays on cytological samples both in interphase and metaphase. autoFIND F provides for the preparation of 1 up to 4 tests/hybridizations on the same slide thanks to the different configurations of the microFIND^® device. It is possible to process up to 16 slides with a maximum of 64 tests per batch. The system permits to perform specific protocols depending on the sample used (cytogenetic pellet or non previously fixed cell) and on specific customer needs. autoFIND F improves throughput, consistency and method standardization. A selection of pre-defined protocols makes it possible to customize the pre-treatment, denaturation and hybridization parameters according to specific specimen requirements. Provided with thermostatic plates and heated housings for the vials, the system can carry out the denaturation of the probes (not supplied with the system) and the following hybridization of the sample with no operator involvement. autoFIND F is realized from the liquid handling Freedom EVO^® system of Tecan AG, for which Tethis developed a set of ad-hoc accessories to adapt the platform to the characteristics of the microFIND^® device.